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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
26.36
Human Site:
S536
Identified Species:
41.43
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
S536
G
D
P
S
E
N
Y
S
K
Y
L
L
S
L
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
S536
G
D
P
S
E
N
Y
S
K
Y
L
L
S
L
K
Dog
Lupus familis
XP_531814
1283
145094
H510
R
F
R
T
L
V
A
H
Y
P
P
V
Q
V
L
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
S535
G
D
P
S
E
N
Y
S
R
Y
L
L
S
L
K
Rat
Rattus norvegicus
XP_002726765
1361
151628
S538
G
D
P
S
E
N
Y
S
R
Y
L
L
S
L
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
N642
I
D
C
D
P
T
E
N
H
N
K
Y
L
L
C
Frog
Xenopus laevis
NP_001089247
1340
149481
S515
G
N
P
S
E
S
H
S
K
Y
L
L
C
F
K
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
S535
G
A
P
S
E
T
Q
S
K
Y
L
L
S
I
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
S431
F
E
D
D
K
N
C
S
R
L
L
T
L
V
S
Honey Bee
Apis mellifera
XP_392346
1120
127429
C361
L
L
S
V
I
E
K
C
P
S
G
S
N
I
S
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
S427
F
E
D
D
D
Y
R
S
Q
L
R
T
L
L
A
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
S508
E
I
A
F
S
R
Y
S
E
T
L
I
Q
K
G
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
R517
R
V
M
V
R
H
T
R
N
P
L
V
N
E
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
A509
P
D
A
S
Y
L
M
A
L
T
E
G
G
E
S
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
E483
T
G
E
L
Q
M
L
E
F
E
D
D
S
E
C
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
0
N.A.
93.3
93.3
N.A.
N.A.
13.3
66.6
73.3
N.A.
20
0
13.3
20
P-Site Similarity:
100
N.A.
100
20
N.A.
100
100
N.A.
N.A.
20
86.6
80
N.A.
46.6
13.3
33.3
33.3
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
6.6
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
14
0
0
0
7
7
0
0
0
0
0
0
7
% A
% Cys:
0
0
7
0
0
0
7
7
0
0
0
0
7
0
14
% C
% Asp:
0
40
14
20
7
0
0
0
0
0
7
7
0
0
0
% D
% Glu:
7
14
7
0
40
7
7
7
7
7
7
0
0
20
0
% E
% Phe:
14
7
0
7
0
0
0
0
7
0
0
0
0
7
0
% F
% Gly:
40
7
0
0
0
0
0
0
0
0
7
7
7
0
7
% G
% His:
0
0
0
0
0
7
7
7
7
0
0
0
0
0
0
% H
% Ile:
7
7
0
0
7
0
0
0
0
0
0
7
0
14
0
% I
% Lys:
0
0
0
0
7
0
7
0
27
0
7
0
0
7
40
% K
% Leu:
7
7
0
7
7
7
7
0
7
14
60
40
20
40
14
% L
% Met:
0
0
7
0
0
7
7
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
0
0
0
34
0
7
7
7
0
0
14
0
0
% N
% Pro:
7
0
40
0
7
0
0
0
7
14
7
0
0
0
0
% P
% Gln:
0
0
0
0
7
0
7
0
7
0
0
0
14
0
0
% Q
% Arg:
14
0
7
0
7
7
7
7
20
0
7
0
0
0
0
% R
% Ser:
0
0
7
47
7
7
0
60
0
7
0
7
40
0
20
% S
% Thr:
7
0
0
7
0
14
7
0
0
14
0
14
0
0
0
% T
% Val:
0
7
0
14
0
7
0
0
0
0
0
14
0
14
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
7
34
0
7
40
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _